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Can I read Tooth Formation as Experimental Model to Study Chemotherapy on Tissue Development: Effect of a Specific Dose of Temozolomide/Veliparib on EtoBox?
Tooth Formation as Experimental Model to Study Chemotherapy on Tissue Development: Effect of a Specific Dose of Temozolomide/Veliparib by Sali Al-Ansari; Rozita Jalali; Antonius L. J. J. Bronckers; Olaf van Tellingen; Judith Raber-Durlacher; Nasser Nadjmi; Alan Henry Brook; Jan de Lange; Frederik R. Rozema is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Tooth Formation as Experimental Model to Study Chemotherapy on Tissue Development: Effect of a Specific Dose of Temozolomide/Veliparib about?
## Background: Chemotherapy treatment of cancer in children can influence formation of normal tissues, leading to irreversible changes in their structure and function. tooth formation is susceptible to several types of chemotherapy that induce irreversible changes in the structure of enamel, dentin and dental root morphology. these changes can make the teeth more prone to fracture or to caries when they have erupted. recent studies report successful treatment of brain tumors with the alkylating drug temozolomide (tmz) in combination with veliparib (vlp) in a glioblastoma in vivo mouse model. whether these drugs also affect tooth formation is unknown. ## Aim: In this study the effect of tmz/vlp on incisor formation was investigated in tissue sections of jaws from mice and compared with mice not treated with these drugs. ## Materials and method: The following aspects were studied using immunohistochemistry of specific protein markers including: (1) proliferation (by protein expression of proliferation marker ki67) (2) a protein involved in ion transport (expression of tight junction (tj) protein claudin-1) and (3) in of ions across the dental epithelium (expression of na+, k+ 2cl- co
Who reads Tooth Formation as Experimental Model to Study Chemotherapy on Tissue Development: Effect of a Specific Dose of Temozolomide/Veliparib?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Sali Al-Ansari; Rozita Jalali; Antonius L. J. J. Bronckers; Olaf van Tellingen; Judith Raber-Durlacher; Nasser Nadjmi; Alan Henry Brook; Jan de Lange; Frederik R. Rozema
- Publisher
- MDPI AG
- Published
- 2022
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)