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Maternal Resveratrol Administration Protects Against Gestational Diabetes‐induced Glucose Intolerance and Islet Dysfunction in the Rat Offspring by Gabriel M. Brawerman; Stephanie M. Kereliuk; Navdeep Brar; Laura K. Cole; Nivedita Seshadri; Troy J. Pereira; Bo Xiang; Kristin L. Hunt; Mario A. Fonseca; Grant M. Hatch; Christine A. Doucette; Vernon W. Dolinsky is a Neuroscience article available to read on EtoBox.
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## Key points Maternal resveratrol (RESV) administration in gestational diabetes (GDM) restored normoglycaemia and insulin secretion. GDM‐induced obesity was prevented in male GDM+RESV offspring but not in females. GDM+RESV offspring exhibited improved glucose tolerance and insulin sensitivity. GDM+RESV restored hepatic glucose homeostasis in offspring. Glucose‐stimulated insulin secretion was enhanced in GDM+RESV offspring. ## Abstract Gestational diabetes (GDM), the most common complication of pregnancy, is associated with adverse metabolic health outcomes in offspring. Using a rat model of diet‐induced GDM, we investigated whether maternal resveratrol (RESV) supplementation (147 mg kg^–1^ day^–1^) in the third week of pregnancy could improve maternal glycaemia and protect the offspring from developing metabolic dysfunction. Female Sprague–Dawley rats consumed a high‐fat and sucrose (HFS) diet to induce GDM. Lean controls consumed a low‐fat (LF) diet. In the third trimester, when maternal hyperglycaemia was observed, the HFS diet was supplemented with RESV. At weaning, offspring were randomly assigned a LF or HFS diet until 15 weeks of age. In pregnant dams, RESV restored glucose
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- Author
- Gabriel M. Brawerman; Stephanie M. Kereliuk; Navdeep Brar; Laura K. Cole; Nivedita Seshadri; Troy J. Pereira; Bo Xiang; Kristin L. Hunt; Mario A. Fonseca; Grant M. Hatch; Christine A. Doucette; Vernon W. Dolinsky
- Publisher
- Wiley
- Published
- 2019
- Language
- EN
- Field
- Neuroscience (Life Sciences)