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**The evaluation of diagnostic and prognostic criteria and the terminology of thin cutaneous malignant melanoma by the CRC Melanoma Pathology Panel** by M.G. COOK; T.J. CLARKE; S. HUMPHREYS; A. FLETCHER; K.M. McLAREN; N.P. SMITH; A. STEVENS; J.M. THEAKER; J. MELIA is a Medicine article available to read on EtoBox.
What is **The evaluation of diagnostic and prognostic criteria and the terminology of thin cutaneous malignant melanoma by the CRC Melanoma Pathology Panel** about?
Sections from 95 skin lesions excised at pigmented lesion clinics in England and Scotland were studied by eight histopathologists in order to evaluate consistency in the use of histopathological terms for features of diagnostic and prognostic importance for cutaneous malignant melanoma. The level of agreement (kappa) amongst the panel improved after discussion and re‐definement of criteria for several features. These included, architectural and nuclear atypia, pagetoid infiltration and radial and vertical growth phases. A high level of agreement was achieved for an overall benign or malignant diagnosis (κ = 0.77) but use of more specific terms such as benign naevi with atypia and melanoma ≤0.76 mm thickness, was associated with only an intermediate level of agreement. Of the original diagnosis of melanoma, 17% were re‐classified by the panel as benign with atypia and 2% reported to be benign were judged to be melanoma. This reflected the high proportion of borderline lesions in the study. The use of standardized diagnostic criteria with precise definitions has been shown to improve consistency in diagnosis and it is recommended for general application. From this should emanate more
Who reads **The evaluation of diagnostic and prognostic criteria and the terminology of thin cutaneous malignant melanoma by the CRC Melanoma Pathology Panel**?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- M.G. COOK; T.J. CLARKE; S. HUMPHREYS; A. FLETCHER; K.M. McLAREN; N.P. SMITH; A. STEVENS; J.M. THEAKER; J. MELIA
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0309-0167)
- Published
- 1996
- Language
- EN
- Field
- Medicine (Health Sciences)