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Can I read Genetic heterogeneity of AIDS-related small non-cleaved cell lymphoma on EtoBox?
Genetic heterogeneity of AIDS-related small non-cleaved cell lymphoma by Gianluca Gaidano; Cristina Pastore; Annunziata Gloghini; Vincenzo Canzonieri; Daniela Capello; Silvia Franceschi; Giuseppe Saglio; Antonino Carbone is a Medicine article available to read on EtoBox.
What is Genetic heterogeneity of AIDS-related small non-cleaved cell lymphoma about?
AIDS-related small noncleaved cell lymphoma (AIDS-SNCCL) includes Burkitt's lymphoma (BL) and high-grade B-cell Burkitt-like lymphoma (BLL). Due to the marked polymorphism of AIDS-related non-Hodgkin's lymphomas (AIDS-NHL), the morphologic distinction between these two types of lymphomas is frequently controversial, although it may bear clinical relevance. Although the molecular features of AIDS-BL have been clarified to a certain extent, the genetic peculiarities of AIDS-BLL have not been investigated in detail. In this study we have compared morphologic and genetic features of AIDS-BL and AIDS-BLL in a blind coded fashion. Molecular studies were focused on the genetic lesions known to be implicated in AIDS-NHL, including alterations of c-MYC, BCL-6, p53, deletions of 6q, as well as infection by EBV and HHV-8. Alterations of c-MYC occurred in 10/10 AIDS-BL, whereas they were restricted to 2/10 AIDS-BLL (P < 0.01). Mutations of p53 were present in 5/10 AIDS-BL, whereas they were consistently absent among AIDS-BLL (n = 10; P < 0.05). Infection by EBV occurred in 30% of both AIDS-BL and AIDS-BLL. Rearrangements of BCL-6, deletions of 6q and infection by HHV-8 scored consistently nega
Who reads Genetic heterogeneity of AIDS-related small non-cleaved cell lymphoma?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Gianluca Gaidano; Cristina Pastore; Annunziata Gloghini; Vincenzo Canzonieri; Daniela Capello; Silvia Franceschi; Giuseppe Saglio; Antonino Carbone
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0007-1048)
- Published
- 1997
- Language
- EN
- Field
- Medicine (Health Sciences)