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P0544inhibition Of 15-hydroxyprostaglandin Dehydrogenase (15-pgdh) Protects Mice Against Contrast-induced Acute Kidney Injury by KIm, Byeong Woo; Kim, Sun hee; Bae, Ki beom is a Medicine article available to read on EtoBox.

What is P0544inhibition Of 15-hydroxyprostaglandin Dehydrogenase (15-pgdh) Protects Mice Against Contrast-induced Acute Kidney Injury about?

## Abstract ## Background and Aims Although the mechanism of contrast-induced acute kidney injury (CI-AKI) is not fully known, the imbalance of vasoconstrictive and vasodilative mediators plays a major role. Prostaglandin E2 (PGE2) is one of the vasodilators involved in this process. Inhibition of 15-hydroxyprostaglandin dehydrogenase (15-PGDH) causes elevation of PGE2 level in tissue by delaying the rapid degradation of PGE2 by the enzyme. We tested the hypothesis that the 15-PGE2 inhibitor would protect against CI-AKI in a mouse model and attempted to elucidate the mechanism involved. ## Method 10-week aged male C57/BL6 Mice were injected with 10gI/kg of iodixanol by tail vein. Renal blood flow measurement, right nephrectomy, and blood sampling were taken at 48 hours after iodixanol injection. The 15-PGDH inhibitor was injected before and after iodixanol administration. Plasma creatinine, NGAL, KIM-1 were measured as biomarkers for renal function. Histological evaluation was analyzed by the necrosis scoring system and TUNEL assay. Arteriolar area of outer medulla was analyzed by α-smooth muscle actin stain. Renal blood flow was measured by the non-invasive laser doppler. ## Resul

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Author

KIm, Byeong Woo; Kim, Sun hee; Bae, Ki beom

Publisher

Oxford University Press; Oxford University Press (OUP) (ISSN 0931-0509)

Published

2020

Language

EN

Field

Medicine (Health Sciences)