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The anti-snake venom properties of Tamarindus indica (leguminosae) seed extract by S. Ushanandini; S. Nagaraju; K. Harish Kumar; M. Vedavathi; D. K. Machiah; K. Kemparaju; B. S. Vishwanath; T. V. Gowda; K. S. Girish is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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## Abstract In Indian traditional medicine, various plants have been used widely as a remedy for treating snakebites. The aim of this study was to evaluate the effect of __Tamarindus indica__ seed extract on the pharmacological as well as the enzymatic effects induced by __V. russelli__ venom. Tamarind seed extract inhibited the PLA~2~, protease, hyaluronidase, l‐amino acid oxidase and 5′‐nucleotidase enzyme activities of venom in a dose‐dependent manner. These are the major hydrolytic enzymes responsible for the early effects of envenomation, such as local tissue damage, inflammation and hypotension. Furthermore, the extract neutralized the degradation of the B__β__ chain of human fibrinogen and indirect hemolysis caused by venom. It was also observed that the extract exerted a moderate effect on the clotting time, prolonging it only to a small extent. Edema, hemorrhage and myotoxic effects including lethality, induced by venom were neutralized significantly when different doses of the extract were preincubated with venom before the assays. On the other hand, animals that received extract 10 min after the injection of venom were protected from venom induced toxicity. Since it inhi

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Author

S. Ushanandini; S. Nagaraju; K. Harish Kumar; M. Vedavathi; D. K. Machiah; K. Kemparaju; B. S. Vishwanath; T. V. Gowda; K. S. Girish

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0951-418X)

Published

2006

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)