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Regenerative potential of epicardium-derived extracellular vesicles mediated by conserved miRNA transfer by Cristina Villa del Campo; Norman Y Liaw; Mala Gunadasa-Rohling; Moritz Matthaei; Luca Braga; Tahnee Kennedy; Gabriela Salinas; Niels Voigt; Mauro Giacca; Wolfram-Hubertus Zimmermann; Paul Richard Riley is a Medicine article available to read on EtoBox.
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## Abstract ## Aims After a myocardial infarction, the adult human heart lacks sufficient regenerative capacity to restore lost tissue, leading to heart failure progression. Finding novel ways to reprogram adult cardiomyocytes into a regenerative state is a major therapeutic goal. The epicardium, the outermost layer of the heart, contributes cardiovascular cell types to the forming heart and is a source of trophic signals to promote heart muscle growth during embryonic development. The epicardium is also essential for heart regeneration in zebrafish and neonatal mice and can be reactivated after injury in adult hearts to improve outcome. A recently identified mechanism of cell–cell communication and signalling is that mediated by extracellular vesicles (EVs). Here, we aimed to investigate epicardial signalling via EV release in response to cardiac injury and as a means to optimize cardiac repair and regeneration. ## Methods and results We isolated epicardial EVs from mouse and human sources and targeted the cardiomyocyte population. Epicardial EVs enhanced proliferation in H9C2 cells and in primary neonatal murine cardiomyocytes in vitro and promoted cell cycle re-entry when inject
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- Author
- Cristina Villa del Campo; Norman Y Liaw; Mala Gunadasa-Rohling; Moritz Matthaei; Luca Braga; Tahnee Kennedy; Gabriela Salinas; Niels Voigt; Mauro Giacca; Wolfram-Hubertus Zimmermann; Paul Richard Riley
- Publisher
- Oxford University Press (OUP)
- Published
- 2021
- Language
- EN
- Field
- Medicine (Health Sciences)