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Can I read Degradation of Chondroitin Sulfate Proteoglycans Potentiates Transplant-mediated Axonal Remodeling and Functional Recovery After Spinal Cord Injury in Adult Rats on EtoBox?
Degradation of Chondroitin Sulfate Proteoglycans Potentiates Transplant-mediated Axonal Remodeling and Functional Recovery After Spinal Cord Injury in Adult Rats by Byung G. Kim; Hai-Ning Dai; James V. Lynskey; Marietta Mcatee; Barbara S. Bregman is a Neuroscience article available to read on EtoBox.
What is Degradation of Chondroitin Sulfate Proteoglycans Potentiates Transplant-mediated Axonal Remodeling and Functional Recovery After Spinal Cord Injury in Adult Rats about?
Transplantation of growth-permissive cells or tissues was used to bridge a lesion cavity and induce axonal growth in experimental spinal cord injury (SCI). Axonal interactions between host and transplant may be affected by upregulation of inhibitory chondroitin sulfate proteoglycans (CSPGs) following various transplantation strategies. The extent of axonal growth and functional recovery after transplantation of embryonic spinal cord tissue decreases in adult compared to neonatal host. We hypothesized that CSPGs contribute to the decrease in the extent to which transplant supports axonal remodeling and functional recovery. Expression of CSPGs increased after overhemisection SCI in adult rats but not in neonates. Embryonic spinal cord transplant was surrounded by CSPGs deposited in host cord, and the interface between host and transplant seemed to contain a large amount of CSPGs. Intrathecally delivered chondroitinase ABC (C'ase) improved recovery of distal forelimb usage and skilled motor behavior after C4 overhemisection injury and transplantation in adults. This behavioral recovery was accompanied by an increased amount of raphespinal axons growing into the transplant, and raphesp
Who reads Degradation of Chondroitin Sulfate Proteoglycans Potentiates Transplant-mediated Axonal Remodeling and Functional Recovery After Spinal Cord Injury in Adult Rats?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Byung G. Kim; Hai-Ning Dai; James V. Lynskey; Marietta Mcatee; Barbara S. Bregman
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 0021-9967)
- Published
- 2006
- Language
- EN
- Field
- Neuroscience (Life Sciences)