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Uvc-induced Cell Death Of Il-2-dependent Human Lymphocytes by E. Radziszewska; K. Piwocka; J. Skierski; E. Sikora is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Uvc-induced Cell Death Of Il-2-dependent Human Lymphocytes about?

We compared the in vitro propensity of human IL-2-dependent lymphocytes (young proliferating and senescent non-proliferating), and resting peripheral blood lymphocytes (PBLs) to undergo UVC-induced apoptosis. The activities of AP-1 (activator protein-1), CRE (cAMP response element) and OCT-1 (octamer-1) transcription factors in all lymphocytes were also assessed. At 24 h after UVC treatment, half of young proliferating T lymphocytes and about a quarter of PBLs and senescent non-proliferating cells were apoptotic, as shown by flow cytometry. However, only in young lymphocytes were both typical DNA 'ladder' and Bcl-2 downregulation evident. The AP-1 transcription factor was activated by UVC in IL-2-dependent young and senescent, but not resting lymphocytes. Taken together, the data show different propensities of resting, proliferating and senescent human lymphocytes to undergo UVCinduced apoptosis and AP-1 activation.

Who reads Uvc-induced Cell Death Of Il-2-dependent Human Lymphocytes?

Author

E. Radziszewska; K. Piwocka; J. Skierski; E. Sikora

Publisher

Elsevier Science; Wiley (John Wiley & Sons); Wiley-Blackwell; Wiley (ISSN 1065-6995)

Published

1999

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)