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The study investigates the use of gemcitabine monophosphate (GMP) formulated into lipid-coated calcium phosphate (LCP) nanoparticles to enhance antitumor immunity against melanoma by depleting myeloid-derived suppressor cells (MDSCs). In a mouse model, LCP-GMP significantly improved apoptosis and reduced immunosuppression in the tumor microenvironment compared to free gemcitabine, leading to enhanced CD8+ T-cell responses and tumor growth inhibition. This research suggests that nanotechnology can effectivel
- Author
- sila.atayildiz
- Language
- EN