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Inhibition of Tumor Invasion and Extracellular Matrix Degradation by Ubenimex (Bestatin) by Junya Yoneda; Ikuo Saiki; Hideji Fujii; Fuminori Abe; Yutaka Kojima; Ichiro Azuma is a Medicine article available to read on EtoBox.

What is Inhibition of Tumor Invasion and Extracellular Matrix Degradation by Ubenimex (Bestatin) about?

We have investigated the effect of the immunomodulator ubenimex (hereafter referred to as bestatin) on the enzymatic degradation of the extracellular matrix by human renal cell carcinoma SN12M cells during the invasive process. The invasion of SN12M cells into reconstituted basement membrane (Matrigel) was inhibited by the presence of bestatin in a concentration-dependent manner. However, bestatin did not have any effect on tumor cell adhesion and migration to the extracellular matrices which may be involved in tumor cell invasion. Bestatin inhibited the degradation of type IV collagen by tumor cells, but not by tumor-conditioned medium (TCM), in a concentration-dependent manner. We also found that bestatin inhibited hydrolysing activities towards substrates of aminopeptidases in SN12M cells. Since bestatin was found to inhibit aminopeptidase activity, the inhibition of tumor invasion by bestatin is likely to be associated with its action as an enzyme inhibitor. Bestatin only slightly inhibited tumor cell plasmin activity, which can lead to the conversion of the latent collagenase to the active form, but this slight effect was not significant. The zymography of TCM from SN12M cells

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Author

Junya Yoneda; Ikuo Saiki; Hideji Fujii; Fuminori Abe; Yutaka Kojima; Ichiro Azuma

Publisher

Springer; Springer-Verlag; Kluwer Academic Publishers; Springer Science and Business Media LLC (ISSN 0262-0898)

Published

1992

Language

EN

Field

Medicine (Health Sciences)