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Role of Host Cervicovaginal Microbiota in Persistence of High-Risk HPV Infection in Women Attending Gynecology Outpatient Department in a Tertiary Hospital by Shakuntala P. Nanaiah; S. M. Rudresh; Renuka Ramaiah is a Medicine article available to read on EtoBox.

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Objective To study the occurrence of high-risk Human Papillomavirus (HR-HPV) infection among women aged 18-45 years with chronic vaginal discharge and to determine the role of cervicovaginal microbiota in the persistence of HR-HPV infection. Methods A prospective cohort study was conducted between January 2018 and December 2020. Four hundred women aged 18-45 years with chronic vaginal discharge were included after obtaining consent. The socioeconomic and demographic details were recorded. Vaginal and endocervical swabs were processed for aerobic bacterial, fungal, and Trichomonas vaginalis culture. The HR-HPV detection was done using HC2 HPV DNA hybridization capture assay. The women who tested positive for HR-HPV were followed-up for 12 months, and repeat HR-HPV screening was done to assess the persistence. Results The mean age of women was 35 years, and most belonged to the lower-income group, and 68% had educational levels above middle school. Lactobacilli were absent in 62.8% of women, and abnormal cervicovaginal microbiota was found among 32.7% of women. Escherichia coli (9.5%), Candida albicans (8%), and non-albicans Candida spp (5.8%) were the most common organisms. HR-HPV w

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Author

Shakuntala P. Nanaiah; S. M. Rudresh; Renuka Ramaiah

Publisher

Springer Science and Business Media LLC

Published

2023

Language

EN

Field

Medicine (Health Sciences)