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A practical guide to chimerism analysis: Review of the literature and testing practices worldwide by Amanda G. Blouin; Fei Ye; Jenifer Williams; Medhat Askar is a Immunology and Microbiology article available to read on EtoBox.

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## Background and purpose: Currently there are no widely accepted guidelines for chimerism analysis testing in hematopoietic cell transplantation (hct) patients. the objective of this review is to provide a practical guide to address key aspects of performing and utilizing chimerism testing results. in developing this guide, we conducted a survey of testing practices among laboratories that are accredited for performing engraftment monitoring/chimerism analysis by either the american society for histocompatibility & immunogenetics (ashi) and/or the european federation of immunogenetics (efi). we interpreted the survey results in the light of pertinent literature as well as the experience in the laboratories of the authors. ## Recent developments: In recent years there has been significant advances in high throughput molecular methods such as next generation sequencing (ngs) as well as growing access to these technologies in histocompatibility and immunogenetics laboratories. these methods have the potential to improve the performance of chimerism testing in terms of sensitivity, availability of informative genetic markers that distinguish donors from recipients as well as cost. ##

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Author

Amanda G. Blouin; Fei Ye; Jenifer Williams; Medhat Askar

Publisher

Elsevier BV

Published

2021

Language

EN

Field

Immunology and Microbiology (Life Sciences)