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The Role of Radioactive Iodine in the Treatment of Advanced Differentiated Thyroid Carcinoma by D. M. V. Pelikan; H. L. Lion; J. Hermans; B. M. Goslings is a Medicine article available to read on EtoBox.

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## OBJECTIVE ^131^I therapy may be beneficial for patients with advanced differentiated thyroid cancer (DTC) but there have been relatively few studies of the prognostic factors which influence the outcome. We have evaluated differences in outcome in relation to histology, localization of tumour, differentiation grade, age and sex after ^131^I as the only secondary treatment for advanced stages of DTC. ## DESIGN Retrospective study of a selected patient group treated according to a fixed protocol. ## PATIENTS We studied the outcome in 86 patients with stage pN3, pT4 or pM1 out of total of 432 patients treated for DTC from 1970 until 1991. ## RESULTS The overall cure rate of ^131^I therapy after a mean follow‐up of 12.1 years was 50% (papillary 65% __vs__ follicular 23%). The overall 5‐year progression free survival (PFSR) was 66%. Three out of 11 patients with bone metastases from follicular cancer were cured after a mean dose of 13.2 GBq, significantly less than the average dose of 28.4 GBq given to all patients with bone metastases. In the univariate analysis of 5‐year PFSR histology (papillary 79% __vs__ follicular 43%), differentiation grade (well differentiated 81% and moderat

Who reads The Role of Radioactive Iodine in the Treatment of Advanced Differentiated Thyroid Carcinoma?

Author

D. M. V. Pelikan; H. L. Lion; J. Hermans; B. M. Goslings

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley; Research Square (ISSN 0300-0664)

Published

1997

Language

EN

Field

Medicine (Health Sciences)