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Side effects of steroid-sparing agents in patients with bullous pemphigoid and pemphigus: A systematic review by Faith A.P. Zeng; Anna Wilson; Tabrez Sheriff; Dedee F. Murrell is a Medicine article available to read on EtoBox.

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## Background Systemic glucocorticoids are first-line treatment options for autoimmune blistering diseases; however, their long-term use is associated with significant toxicities. ## Objective To evaluate the side effects of steroid-sparing agents and compare them with those of steroids. ## Methods We searched Cochrane Reviews, Embase, MEDLINE, and Scopus between October 1978 and May 2020 using the keywords “bullous pemphigoid,” “pemphigus,” “autoimmune blistering diseases,” and “side effects.” A total of 31 randomized controlled trials and retrospective case series were critically appraised. ## Results This review includes a total of 1685 patients with autoimmune blistering diseases, of whom 781 had bullous pemphigoid and 904 had either pemphigus vulgaris or pemphigus foliaceous. ## Limitations A major limitation is that because adjuvants are generally used in combination with steroids, only 12 of the studies reviewed included a “steroid-only” arm to allow for a direct comparison of side effects. Additionally, there is inadequate literature and lack of standardized grade reporting of specific side effects of each steroid-sparing agent. ## Conclusion In the future, researchers shou

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Author

Faith A.P. Zeng; Anna Wilson; Tabrez Sheriff; Dedee F. Murrell

Publisher

Elsevier BV

Published

2022

Language

EN

Field

Medicine (Health Sciences)