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Retinal regeneration requires dynamic Notch signaling by DavidR Hyde; LeahJ Campbell; JaclynL Levendusky; ShannonA Steines is a Neuroscience article available to read on EtoBox.

What is Retinal regeneration requires dynamic Notch signaling about?

Retinal damage in the adult zebrafish induces Müller glia reprogramming to produce neuronal progenitor cells that proliferate and differentiate into retinal neurons. Notch signaling, which is a fundamental mechanism known to drive cell-cell communication, is required to maintain Müller glia in a quiescent state in the undamaged retina, and repression of Notch signaling is necessary for Müller glia to reenter the cell cycle. The dynamic regulation of Notch signaling following retinal damage also directs proliferation and neurogenesis of the Müller glia-derived progenitor cells in a robust regeneration response. In contrast, mammalian Müller glia respond to retinal damage by entering a prolonged gliotic state that leads to additional neuronal death and permanent vision loss. Understanding the dynamic regulation of Notch signaling in the zebrafish retina may aid efforts to stimulate Müller glia reprogramming for regeneration of the diseased human retina. Recent findings identified DeltaB and Notch3 as the ligand-receptor pair that serves as the principal regulators of zebrafish Müller glia quiescence. In addition, multiomics datasets and functional studies indicate that additional Not

Who reads Retinal regeneration requires dynamic Notch signaling?

Author

DavidR Hyde; LeahJ Campbell; JaclynL Levendusky; ShannonA Steines

Published

2021

Language

EN

Field

Neuroscience (Life Sciences)