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Cellular and humoral functional responses after BNT162b2 mRNA vaccination differ longitudinally between naive and subjects recovered from COVID-19 by Roberto Lozano-Rodríguez; Jaime Valentín-Quiroga; José Avendaño-Ortiz; Alejandro Martín-Quirós; Alejandro Pascual-Iglesias; Verónica Terrón-Arcos; Karla Montalbán-Hernández; José Carlos Casalvilla-Dueñas; Marta Bergón-Gutiérrez; José Alcamí; Javier García-Pérez; Almudena Cascajero; Miguel Ángel García-Garrido; Álvaro del Balzo-Castillo; María Peinado; Laura Gómez; Irene Llorente-Fernández; Gema Martín-Miguel; Carmen Herrero-Benito; José Miguel Benito; Norma Rallón; Carmen Vela-Olmo; Lissette López-Morejón; Carolina Cubillos-Zapata; Luis A. Aguirre; Carlos del Fresno; Eduardo López-Collazo is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Cellular and humoral functional responses after BNT162b2 mRNA vaccination differ longitudinally between naive and subjects recovered from COVID-19 about?

We have analyzed BNT162b2 vaccine-induced immune responses in naive subjects and individuals recovered from coronavirus disease 2019 (COVID-19), both soon after (14 days) and later after (almost 8 months) vaccination. Plasma spike (S)-specific immunoglobulins peak after one vaccine shot in individuals recovered from COVID-19, while a second dose is needed in naive subjects, although the latter group shows reduced levels all along the analyzed period. Despite how the neutralization capacity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mirrors this behavior early after vaccination, both groups show comparable neutralizing antibodies and S-specific B cell levels late post-vaccination. When studying cellular responses, naive individuals exhibit higher SARS-CoV-2-specific cytokine production, CD4 T cell activation, and proliferation than do individuals recovered from COVID-19, with patent inverse correlations between humoral and cellular variables early post-vaccination. However, almost 8 months post-vaccination, SARS-CoV-2-specific responses are comparable between both groups. Our data indicate that a previous history of COVID-19 differentially determines the fu

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Author

Roberto Lozano-Rodríguez; Jaime Valentín-Quiroga; José Avendaño-Ortiz; Alejandro Martín-Quirós; Alejandro Pascual-Iglesias; Verónica Terrón-Arcos; Karla Montalbán-Hernández; José Carlos Casalvilla-Dueñas; Marta Bergón-Gutiérrez; José Alcamí; Javier García-Pérez; Almudena Cascajero; Miguel Ángel García-Garrido; Álvaro del Balzo-Castillo; María Peinado; Laura Gómez; Irene Llorente-Fernández; Gema Martín-Miguel; Carmen Herrero-Benito; José Miguel Benito; Norma Rallón; Carmen Vela-Olmo; Lissette López-Morejón; Carolina Cubillos-Zapata; Luis A. Aguirre; Carlos del Fresno; Eduardo López-Collazo

Publisher

Elsevier BV

Published

2022

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)