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Efficacy and Expenses of Succimer vs. D-penicillamine Plus Garlic in the Treatment of Lead Poisoning: a Retrospective Cross-sectional Study by Maryam Vahabzadeh; Mahdi Balali-mood; Ali Banagozar Mohammadi; Mohammad Moshiri is a Pharmacology, Toxicology and Pharmaceutics article available to read on EtoBox.

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## Purpose: Lead poisoning is a major health problem in iran. we aimed to compare efficacy of a standard regimen (succimer) with that of a low-priced combination of d-penicillamine and garlic in outpatients with lead poisoning. ## Methods: In this retrospective cross-sectional study, year-long clinical files of outpatients with lead poisoning in two referral toxicology clinics in mashhad, iran were reviewed. a total of 79 patients (all men), received either succimer or a combination of d-penicillamen plus garlic (dpn + gar), for 19 and 30 days, respectively. clinical and laboratory data, including blood lead level (bll), were analyzed and treatment expanses were compared between the two regimens. ## Results: Of 79 male patients, 42 were treated by dpn + gar and 37 received succimer. mean bll of dpn + gar group before treatment (965.73 ± 62.54 μg/l) was higher than that of the succimer group (827.59 ± 24.41) (p < 0.001). after treatment, bll in both groups significantly reduced to 365.52 ± 27.61 μg/l and 337.44 ± 26.34 μg/l, respectively (p < 0.001). the price of a 19-day treatment with succimer was approximately 28.6 times higher than a one-month course of treatment with garlic plu

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Author

Maryam Vahabzadeh; Mahdi Balali-mood; Ali Banagozar Mohammadi; Mohammad Moshiri

Publisher

Springer Science and Business Media LLC

Published

2021

Language

EN

Field

Pharmacology, Toxicology and Pharmaceutics (Life Sciences)