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Pneumonia after bacterial or viral infection preceded or followed by radiation exposure -- a reanalysis of older radiobiological data and implications for low dose radiotherapy for COVID-19 pneumonia by Little, Mark P; Zhang, Wei; van Dusen, Roy; Hamada, Nobuyuki is a scholarly article available to read on EtoBox.

What is Pneumonia after bacterial or viral infection preceded or followed by radiation exposure -- a reanalysis of older radiobiological data and implications for low dose radiotherapy for COVID-19 pneumonia about?

Currently, there are 14 ongoing clinical studies on low dose radiotherapy (LDRT) for COVID-19 pneumonia. An underlying assumption is that irradiation of about 1 Gy is effective at ameliorating viral pneumonia. Its rationale, however, relies on early human case series or animal studies mostly obtained in the pre-antibiotic era, where rigorous statistical analyses were not performed. It therefore remains unclear whether those early data support such assumptions. With standard statistical survival models, and based on a systematic literature review, we re-analyzed 14 radiobiological animal datasets in which animals received mostly fractionated doses of radiation before or after bacterial/viral inoculation, and assessing various health endpoints (mortality, pneumonia morbidity). In most datasets absorbed doses did not exceed 7 Gy. Various different model systems and types of challenging infection are considered. For 7 studies that evaluated post-inoculation radiation exposure (more relevant to LDRT for COVID-19 pneumonia) the results are heterogeneous, with 2 studies showing a significant increase (p<0.001) and another showing a significant decrease (p<0.001) in mortality associated wi

Author

Little, Mark P; Zhang, Wei; van Dusen, Roy; Hamada, Nobuyuki

Published

2020

Language

EN