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Polymerase θ: DNA Repair Mechanism Insights by 王明軍 is a document available to read on EtoBox.

The study investigates the role of human polymerase θ (Polθ) helicase in DNA double-strand break repair, focusing on its ability to position DNA microhomologies for error-prone repair mechanisms. Using cryo-electron microscopy, the researchers reveal structural changes in the helicase upon binding to DNA, which facilitate the annealing of complementary DNA strands. The findings suggest that Polθ is a promising therapeutic target for cancers associated with DNA repair deficiencies, as its inhibition could ex

Author

王明軍

Language

EN