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Flow Dynamics in Bioreactors Containing Tissue Engineering Scaffolds by Benjamin J. Lawrence; Mamatha Devarapalli; Sundararajan V. Madihally is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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## Abstract Bioreactors are widely used in tissue engineering as a way to distribute nutrients within porous materials and provide physical stimulus required by many tissues. However, the fluid dynamics within the large porous structure are not well understood. In this study, we explored the effect of reactor geometry by using rectangular and circular reactors with three different inlet and outlet patterns. Geometries were simulated with and without the porous structure using the computational fluid dynamics software Comsol Multiphysics 3.4 and/or ANSYS CFX 11 respectively. Residence time distribution analysis using a step change of a tracer within the reactor revealed non‐ideal fluid distribution characteristics within the reactors. The Brinkman equation was used to model the permeability characteristics with in the chitosan porous structure. Pore size was varied from 10 to 200 μm and the number of pores per unit area was varied from 15 to 1,500 pores/mm^2^. Effect of cellular growth and tissue remodeling on flow distribution was also assessed by changing the pore size (85–10 μm) while keeping the number of pores per unit area constant. These results showed significant increase in

Who reads Flow Dynamics in Bioreactors Containing Tissue Engineering Scaffolds?

Author

Benjamin J. Lawrence; Mamatha Devarapalli; Sundararajan V. Madihally

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); Wiley - V C H Verlag GmbbH & Co.; Wiley (ISSN 0006-3592)

Published

2008

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)