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Preparative chromatography with supercritical fluids: Comparison of simulated moving bed and batch processes by Stephanie Peper; Monika Johannsen; Gerd Brunner is a Chemistry article available to read on EtoBox.

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Preparative chromatography is a key technology for the separation of fine chemicals in production scale. Most of the published studies are carried out using liquid solvents as mobile phase. However, the used organic solvents can often be replaced by supercritical fluids. A reduction or renouncement of organic solvents does not only correspond to the trend of the so-called green chemistry-a sustainable, environmentally friendly production of chemical products. But a changeover to chromatography with supercritical fluids can also be reasonable under economic criteria. In this contribution a comparison between the Batch-supercritical fluid chromatography (Batch-SFC) process and the simulated moving bed (SMB)-SFC process is presented. Because of the minor importance of solvent consumption and solvent recovery in SFC, the separation systems were optimized primarily in terms of their specific productivity. For three of the four investigated model systems, the specific productivity of the SMB process is significantly higher than the productivity of the Batch process. Due to the fact, that the process with the higher specific productivity is not inevitably the more economical process, supp

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Author

Stephanie Peper; Monika Johannsen; Gerd Brunner

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 1873-3778)

Published

2007

Language

EN

Field

Chemistry (Physical Sciences)