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The Impact of Extended Half‐Life Factor Concentrates on Prophylaxis for Severe Hemophilia in The United States by Malec, Lynn M.; Cheng, Dunlei; Witmer, Char M.; Jaffray, Julie; Kouides, Peter A.; Haley, Kristina M.; Sidonio, Robert F.; Johnson, Kelsey; Recht, Michael; White, Gilbert; Croteau, Stacy E.; Ragni, Margaret V. is a Medicine article available to read on EtoBox.

What is The Impact of Extended Half‐Life Factor Concentrates on Prophylaxis for Severe Hemophilia in The United States about?

With licensure of extended half-life (EHL) factor products and the changing landscape of available hemophilia products, patients and providers have options for less treatment-intense prophylaxis. The impact of these products in clinical practice to date remains understudied. We aimed to quantify the use of EHL products in prophylaxis in the US using the ATHN-dataset, a database of 145 ATHN-affiliated hemophilia treatment centers (HTCs). Further, we aimed to quantify the impact of EHL on key hemophilia indicators including annualized bleed rates (ABRs), hemophilia joint health scores (HJHS) and quality of life (QOL) metrics. The use of EHL vs standard half-life (SHL) products in severe hemophilia was compared between June 2018 and March 2019 using the ATHN-dataset. A cohort of patients was also recruited from seven participating HTCs in order to compare ABR, HJHS and QOL between product classes. By March 2019 the number of individuals with severe Hemophilia A (SHA) receiving EHLs remained relatively stable (28.4%), whereas the number of prescribed non-factor products increased to 7.1%, with a diminishing majority of patients (64.0%) continuing to receive SHLs. The majority of patien

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Author
Malec, Lynn M.; Cheng, Dunlei; Witmer, Char M.; Jaffray, Julie; Kouides, Peter A.; Haley, Kristina M.; Sidonio, Robert F.; Johnson, Kelsey; Recht, Michael; White, Gilbert; Croteau, Stacy E.; Ragni, Margaret V.
Publisher
John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 0361-8609)
Published
2020
Language
EN
Field
Medicine (Health Sciences)

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Browse all works by Malec, Lynn M.; Cheng, Dunlei; Witmer, Char M.; Jaffray, Julie; Kouides, Peter A.; Haley, Kristina M.; Sidonio, Robert F.; Johnson, Kelsey; Recht, Michael; White, Gilbert; Croteau, Stacy E.; Ragni, Margaret V.