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Migraine-Associated Common Genetic Variants Confer Greater Risk of Posterior vs. Anterior Circulation Ischemic Stroke* 1 Introduction 2 Materials and methods 2 Ischemic stroke population 2 Ischemic stroke cohort genotyping 3 Imputation and post-imputation quality control (QC) 3 Non-stroke control subjects 3 Migraine GWAS data 3 Polygenic risk scores 3 Data availability 4 Statistical analyses 4 Standard protocol approvals, registrations and patient consents 4 Results 4 Primary analyses 4 Migraine PRSs in PCiS vs. ACiS subjects: analysis in EUR samples 4 Any migraine (M) 4 Migraine without aura (MO) 5 Migraine with aura (MA) 5 Secondary analyses 5 Migraine PRSs in PCiS and ACiS separately vs. non-stroke control subjects: analyses in EUR samples 5 Any migraine (M) 5 Migraine without aura (MO) 5 Migraine with aura (MA) 5 Migraine PRSs in PCiS vs. ACiS in EUR and AFR samples 5 Migraine PRSs in PCiS and ACiS separately vs. non-stroke control subjects in EUR and AFR samples 6 Any migraine (M) 6 Migraine without aura (MO) 6 Migraine with aura (MA) 6 Discussion 6 Strengths 7 Limitations 8 Conclusion 8 Disclosures 8 Sources of funding 8 REFERENCES 9

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Language

UND

Category

nonfiction