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Immunological and Prognostic Significance of Tumour Necrosis in Colorectal Cancer by Meeri Kastinen; Päivi Sirniö; Hanna Elomaa; Maarit Ahtiainen; Sara A. Väyrynen; Karl-Heinz Herzig; Sanna Meriläinen; Raila Aro; Reetta Häivälä; Tero Rautio; Juha Saarnio; Erkki-Ville Wirta; Olli Helminen; Toni T. Seppälä; Teijo Kuopio; Jan Böhm; Anne Tuomisto; Jukka-Pekka Mecklin; Markus J. Mäkinen; Juha P. Väyrynen is a Medicine article available to read on EtoBox.
What is Immunological and Prognostic Significance of Tumour Necrosis in Colorectal Cancer about?
## Background Colorectal cancer (CRC) causes the second most cancer deaths worldwide, but the disease course varies according to tumour characteristics and immunological factors. Our objective was to examine the associations of tumour necrosis with tumour characteristics, immune cell infiltrates, serum cytokine concentrations, as well as prognosis in CRC. ## Methods Three independent CRC cohorts, including 1413 patients, were analysed. Associations of the areal percentage of tumour necrosis with clinicopathologic parameters, tumour infiltrating immune cells, cytokine concentrations in systemic and mesenteric vein blood, and survival were examined. ## Results Higher tumour necrosis percentage associated with shorter colorectal cancer-specific survival independent of tumour grade, T, N or M-class, mismatch repair status, __BRAF__ status, and other possible confounding factors. In the largest cohort (__N__ = 1100), the HR for high tumour necrosis percentage (≥40% vs. <3%) was 3.22 (95% CI 1.68–6.17, __P__~trend~ < 0.0001). Tumour necrosis percentage positively correlated with peripheral serum levels of CXCL8, a proinflammatory chemokine, and negatively correlated with mesenteric serum
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- Author
- Meeri Kastinen; Päivi Sirniö; Hanna Elomaa; Maarit Ahtiainen; Sara A. Väyrynen; Karl-Heinz Herzig; Sanna Meriläinen; Raila Aro; Reetta Häivälä; Tero Rautio; Juha Saarnio; Erkki-Ville Wirta; Olli Helminen; Toni T. Seppälä; Teijo Kuopio; Jan Böhm; Anne Tuomisto; Jukka-Pekka Mecklin; Markus J. Mäkinen; Juha P. Väyrynen
- Publisher
- Springer Science and Business Media LLC
- Published
- 2023
- Language
- EN
- Field
- Medicine (Health Sciences)