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D2-mediated modulation of N-type calcium currents in rat globus pallidus neurons following dopamine denervation by Alessandro Stefani; Francesca Spadoni; Alessandro Martorana; Franco Lavaroni; Giuseppina Martella; Giuseppe Sancesario; Giorgio Bernardi is a Neuroscience article available to read on EtoBox.
What is D2-mediated modulation of N-type calcium currents in rat globus pallidus neurons following dopamine denervation about?
## Abstract We have studied the effects of dopamine and the D2‐like agonist quinpirole on calcium currents of neurons isolated from the striatum and the globus pallidus (GP). Experiments were performed in young adult rats, either in control conditions or following lesion of the nigrostriatal pathway by the unilateral injection of 6‐hydroxydopamine (6‐OHDA) in the substantia nigra. Apomorphine‐driven contralateral turning, 15 days after lesioning, assessed the severity of the dopamine denervation. In addition, the loss of tyrosine hydroxylase immunohistochemistry confirmed the extent of the toxin‐induced damage. In both striatal medium spiny (MS) and GP neurons of control animals dopamine and quinpirole promoted a very modest inhibition of calcium conductance. Following 6‐OHDA, the inhibition was unaltered in MS (from 10 to 12%), but significantly augmented in GP neurons (21% vs. 9%). Interestingly, analogous inhibition was observed in GP neurons dissociated 20 h after reserpine treatment. Further features of the D2 response were thus studied only in neurons isolated from 6‐OHDA‐lesioned GP. The D2 modulation was G‐protein‐mediated but not strictly voltage‐dependent. ω‐Conotoxin‐GVI
Who reads D2-mediated modulation of N-type calcium currents in rat globus pallidus neurons following dopamine denervation?
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- Author
- Alessandro Stefani; Francesca Spadoni; Alessandro Martorana; Franco Lavaroni; Giuseppina Martella; Giuseppe Sancesario; Giorgio Bernardi
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0953-816X)
- Published
- 2002
- Language
- EN
- Field
- Neuroscience (Life Sciences)