Can I read Inhibitors of Farnesyl Protein Transferase. Synthesis and Biological Activity of Amide and Cyanoguanidine Derivatives Containing a 5,11-Dihydro[1]benzthiepin, Benzoxepin, and Benzazepin [4,3-B]pyridine Ring System on EtoBox?

Inhibitors of Farnesyl Protein Transferase. Synthesis and Biological Activity of Amide and Cyanoguanidine Derivatives Containing a 5,11-Dihydro[1]benzthiepin, Benzoxepin, and Benzazepin [4,3-B]pyridine Ring System by Ronald Wolin; Michael Connolly; Joseph Kelly; Jay Weinstein; Stuart Rosenblum; Adriano Afonso; Linda James; Paul Kirschmeier; W. Robert Bishop is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Inhibitors of Farnesyl Protein Transferase. Synthesis and Biological Activity of Amide and Cyanoguanidine Derivatives Containing a 5,11-Dihydro[1]benzthiepin, Benzoxepin, and Benzazepin [4,3-B]pyridine Ring System about?

Bioisosteric replacement of the C-6 carbon atom in piperidine I and piperazine II with S, 0, and N heteroatoms is described. Amide and cyanoguanidine derivatives of these compounds were evaluated in vitro and found to be good inhibitors of famesyl-protein transferase. An improved method of preparing the $11.dihydro- [ l]-benzthiepin nucleus 6 was accomplished in high yield and with excellent regioselectivity using an AlC13 melt prOtoCO1.

Who reads Inhibitors of Farnesyl Protein Transferase. Synthesis and Biological Activity of Amide and Cyanoguanidine Derivatives Containing a 5,11-Dihydro[1]benzthiepin, Benzoxepin, and Benzazepin [4,3-B]pyridine Ring System?

Author

Ronald Wolin; Michael Connolly; Joseph Kelly; Jay Weinstein; Stuart Rosenblum; Adriano Afonso; Linda James; Paul Kirschmeier; W. Robert Bishop

Publisher

Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0960-894X)

Published

1998

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)