Can I read Mechanisms of chromium (VI)-induced apoptosis in anterior pituitary cells on EtoBox?

Mechanisms of chromium (VI)-induced apoptosis in anterior pituitary cells by Fernanda A. Quinteros; Leticia I. Machiavelli; Eliana A. Miler; Jimena P. Cabilla; Beatriz H. Duvilanski is a Environmental Science article available to read on EtoBox.

What is Mechanisms of chromium (VI)-induced apoptosis in anterior pituitary cells about?

Hexavalent chromium (Cr (VI)) is a highly toxic metal. Exposure to Cr (VI) compounds may affect reproductive functions. Due to the importance of anterior pituitary hormones on reproductive physiology we have studied the effects of Cr (VI) on anterior pituitary. We previously demonstrated that, after in vivo Cr (VI) administration, Cr accumulates in the pituitary gland and affects prolactin secretion. In vitro, Cr (VI) causes apoptosis in anterior pituitary cells due to oxidative stress generation. To better understand the mechanisms involved in Cr (VI)-induced apoptosis we studied: (a) whether Cr (VI) affects the intracellular antioxidant response and (b) which of the apoptotic factors participates in Cr (VI) effect. Our results show that Cr (VI) treatment induces a decrease in catalase and glutathione peroxidase (GPx) activity but does not modify glutathione reductase (GR) activity. Cr (VI) exposure causes an increase of GSH levels. p53 and Bax mRNA are also upregulated by the metal. Pifithrin alpha, a p53 transcriptional inhibitor, increases Cr (VI) cytotoxicity, suggesting a role of p53 as a survival molecule. The antioxidant N-acetyl-cysteine (NAC) could prevent Bax mRNA increa

Who reads Mechanisms of chromium (VI)-induced apoptosis in anterior pituitary cells?

Author

Fernanda A. Quinteros; Leticia I. Machiavelli; Eliana A. Miler; Jimena P. Cabilla; Beatriz H. Duvilanski

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0300-483X)

Published

2008

Language

EN

Field

Environmental Science (Life Sciences)