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Epidemiology of HPV genotypes in Uganda and the role of the current preventive vaccines: A systematic review by Cecily Banura; Florence M Mirembe; Anne R Katahoire; Proscovia B Namujju; Anthony K Mbonye; Fred M Wabwire is a Medicine article available to read on EtoBox.

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## Background Limited data are available on the distribution of human papillomavirus (HPV) genotypes in the general population and in invasive cervical cancer (ICC) in Uganda. Yet, with the advent of preventive HPV vaccines that target HPV 16 and 18 responsible for causing about 70% of ICC cases in the world, such information is crucial to predict how vaccination and HPV-based screening will influence prevention of ICC. ## Methods To review the distribution of HPV infection and prevalent genotypes, electronic databases (e.g. PubMed/MEDLINE and HINARI) were searched for peer reviewed English articles on HPV infection up to November 30, 2010. Eligible studies were selected according to the following criteria: DNA-confirmed cervical or male genital HPV prevalence and genotypes, HPV incidence estimates and HPV seroprevalence among participants. ## Results Twenty studies were included in the review. Among HIV negative adult women, the prevalence of HR-HPV infections ranged from 10.2% -40.0% compared to 37.0% -100.0% among HIV positive women. Among HIV positive young women aged below 25 years, the prevalence of HR-HPV genotypes ranged from 41.6% -75.0% compared to 23.7% -67.1% among HIV

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Author

Cecily Banura; Florence M Mirembe; Anne R Katahoire; Proscovia B Namujju; Anthony K Mbonye; Fred M Wabwire

Publisher

BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central, 2006-; Springer Science and Business Media LLC (ISSN 1750-9378)

Published

2011

Language

EN

Field

Medicine (Health Sciences)