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Severe burns cause skeletal muscle mitochondria to become more thermogenic and less efficient at ATP production. This mitochondrial uncoupling persists for years and contributes to prolonged hypermetabolism and muscle wasting post-burn. Studies found burned adults and children had reduced mitochondrial density and coupling control in muscle tissue, leading to greater oxygen consumption being used for heat generation rather than phosphorylation. While this may help regulate temperature after losing the skin

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api-383975700

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