Opening book details…
Can I read The interaction between HLA shared epitope alleles and smoking and its contribution to autoimmunity against several citrullinated antigens on EtoBox?
The interaction between HLA shared epitope alleles and smoking and its contribution to autoimmunity against several citrullinated antigens by Annemiek Willemze; Diane van der Woude; Wendimagegn Ghidey; E. W. Nivine Levarht; Gerrie Stoeken-Rijsbergen; Willem Verduyn; René R. P. de Vries; Jeanine J. Houwing-Duistermaat; Tom W. J. Huizinga; Leendert A. Trouw; René E. M. Toes is a Medicine article available to read on EtoBox.
What is The interaction between HLA shared epitope alleles and smoking and its contribution to autoimmunity against several citrullinated antigens about?
Objective. Recent data suggest that a geneenvironment interaction between smoking and the HLA shared epitope alleles plays a role in shaping the autoimmune reaction to specific citrullinated antigens. This study was undertaken to determine the effects of HLA shared epitope alleles and tobacco exposure on the immune response against various citrullinated antigens. These associations were analyzed in the anticitrullinated protein antibody (ACPA)-positive stratum to control for the possibility that the associations found are explained by the known interaction between HLA shared epitope alleles and tobacco exposure on ACPA status. Methods. In 661 patients with rheumatoid arthri-tis, reactivity against several citrullinated antigens from vimentin, fibrinogen, enolase, and myelin basic protein was determined by enzyme-linked immunosorbent assay. The effects of the HLA shared epitope alleles and tobacco exposure were assessed by logistic regression analysis. Biologic interaction was analyzed by investigating whether the effects of the risk factors combined exhibited departure from additivity. Results. A significant interaction between tobacco exposure and HLA shared epitope alleles was fo
Who reads The interaction between HLA shared epitope alleles and smoking and its contribution to autoimmunity against several citrullinated antigens?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Annemiek Willemze; Diane van der Woude; Wendimagegn Ghidey; E. W. Nivine Levarht; Gerrie Stoeken-Rijsbergen; Willem Verduyn; René R. P. de Vries; Jeanine J. Houwing-Duistermaat; Tom W. J. Huizinga; Leendert A. Trouw; René E. M. Toes
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0004-3591)
- Published
- 2011
- Language
- EN
- Field
- Medicine (Health Sciences)