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Prenatal exposure to pregabalin, birth outcomes and neurodevelopment – a population-based cohort study in four Nordic countries by Elena Dudukina; Szimonetta Komjáthiné Szépligeti; Pär Karlsson; Kofi Asomaning; Anne Kjersti Daltveit; Katja Hakkarainen; Fabian Hoti; Helle Kieler; Astrid Lunde; Ingvild Odsbu; Matti Rantanen; Johan Reutfors; Laura Saarelainen; Vera Ehrenstein; Gunnar Toft is a Medicine article available to read on EtoBox.

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## Introduction Pregabalin is an antiepileptic drug frequently prescribed to pregnant women. Risks of adverse birth and postnatal neurodevelopmental outcomes following prenatal exposure to pregabalin are uncertain. ## Objective To investigate the association between prenatal exposure to pregabalin and the risks of adverse birth and postnatal neurodevelopmental outcomes. ## Methods This study was conducted using population-based registries in Denmark, Finland, Norway, and Sweden (2005–2016). We compared pregabalin exposure against no exposure to antiepileptics and against active comparators lamotrigine and duloxetine. We obtained pooled propensity score-adjusted estimates of association using fixed-effect and Mantel–Haenszel (MH) meta-analyses. ## Results The total number of pregabalin-exposed births was 325/666,139 (0.05%) in Denmark, 965/643,088 (0.15%) in Finland, 307/657,451 (0.05%) in Norway, and 1275/1,152,002 (0.11%) in Sweden. The adjusted prevalence ratios (aPRs) with 95% confidence interval (CI) following pregabalin exposure versus no exposure were 1.14 (0.98–1.34) for major congenital malformations and 1.72 (1.02–2.91) for stillbirth, which attenuated to 1.25 (0.74–2.11)

Who reads Prenatal exposure to pregabalin, birth outcomes and neurodevelopment – a population-based cohort study in four Nordic countries?

Author

Elena Dudukina; Szimonetta Komjáthiné Szépligeti; Pär Karlsson; Kofi Asomaning; Anne Kjersti Daltveit; Katja Hakkarainen; Fabian Hoti; Helle Kieler; Astrid Lunde; Ingvild Odsbu; Matti Rantanen; Johan Reutfors; Laura Saarelainen; Vera Ehrenstein; Gunnar Toft

Publisher

Springer Science and Business Media LLC

Published

2023

Language

EN

Field

Medicine (Health Sciences)