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Duloxetine for Fibromyalgia Syndrome: a Systematic Review and Meta-analysis by Filippo Migliorini; Nicola Maffulli; Jörg Eschweiler; Alice Baroncini; Andreas Bell; Giorgia Colarossi is a Medicine article available to read on EtoBox.

What is Duloxetine for Fibromyalgia Syndrome: a Systematic Review and Meta-analysis about?

## Introduction The optimal dose of duloxetine in the management of fibromyalgia remains still controversial. Therefore, a systematic review and meta-analysis to investigate efficacy and safety of duloxetine was conducted. The outcomes of interests were to assess changes in Fibromyalgia Impact Questionnaire (FIQ), Brief Pain Inventory (BPI), and Clinical Global Impression (CGI). The rate of of adverse events and those leading to therapy discontinuation were also investigated. ## Material and methods This study followed the 2020 PRISMA guidelines. The literature search started in December 2022 accessing PubMed, Google scholar, Embase, and Scopus databases. All the RCTs investigating the efficacy and safety of daily administration of duloxetine for fibromyalgia were accessed. Studies reporting quantitative data under the outcomes of interest, and including a minimum of 10 patients who completed a minimum of 4 weeks follow-up, were included. Studies on combined pharmacological and non-pharmacological managements for fibromyalgia were not considered. ## Results Data from 3432 patients (11 RCTs) were included. The mean age of the patients was 46.4 ± 10.7 years old, and the mean BMI 25.3

Who reads Duloxetine for Fibromyalgia Syndrome: a Systematic Review and Meta-analysis?

Author

Filippo Migliorini; Nicola Maffulli; Jörg Eschweiler; Alice Baroncini; Andreas Bell; Giorgia Colarossi

Publisher

Springer Science and Business Media LLC

Published

2023

Language

EN

Field

Medicine (Health Sciences)