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What is SAR of Thiazide Diuretics about?

Diuretics are drugs that promote increased production of urine. Thiazide diuretics are structurally related compounds that inhibit sodium reabsorption in the distal convoluted tubule of the kidney. Key structural features that influence thiazide diuretic activity include substitutions at positions 2, 3, 4, 6, and 7 of the thiazide ring system. Carbonic anhydrase inhibitors like acetazolamide reversibly inhibit the carbonic anhydrase enzyme, slowing hydration of carbon dioxide and decreasing hydrogen ion exc

Author
Tikendra
Language
EN