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Smell Changes and Efficacy of Nasal Theophylline (SCENT) irrigation: A randomized controlled trial for treatment of post-viral olfactory dysfunction by Jake J. Lee; Andrew M. Peterson; Dorina Kallogjeri; Pawina Jiramongkolchai; Sara Kukuljan; John S. Schneider; Cristine N. Klatt-Cromwell; Andrew J. Drescher; Joseph D. Brunworth; Jay F. Piccirillo is a Medicine article available to read on EtoBox.
What is Smell Changes and Efficacy of Nasal Theophylline (SCENT) irrigation: A randomized controlled trial for treatment of post-viral olfactory dysfunction about?
## Objective: To evaluate the efficacy and safety of intranasal theophylline saline irrigation on olfactory recovery in patients with post-viral olfactory dysfunction (pvod). ## Methods: Between may 2019 and april 2020, we conducted a double-blinded, placebo-controlled randomized clinical trial of adults with 6-36 months of pvod. patients were randomized to nasal theophylline saline irrigation or placebo saline irrigation twice a day for 6 weeks. the primary outcome was the global rating of smell change. secondary outcomes were changes in the university of pennsylvania smell identification test (upsit) and questionnaire of olfactory disorders-negative statements (qod-ns). ## Results: Twenty-two patients (n = 12, theophylline; n = 10, placebo) completed the study. slightly more patients in the theophylline group (33%) reported improved smell compared to the placebo group (30%, difference 3.3%, 95% ci -35.6% to 42.3%). the median differences in pre- and post-treatment upsit and qod-ns change between the two groups were 1 (95% ci -3 to 5) and -10 (95% ci -15 to -4), respectively in favor of theophylline. three patients receiving theophylline and 2 receiving placebo had clinically mean
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- Author
- Jake J. Lee; Andrew M. Peterson; Dorina Kallogjeri; Pawina Jiramongkolchai; Sara Kukuljan; John S. Schneider; Cristine N. Klatt-Cromwell; Andrew J. Drescher; Joseph D. Brunworth; Jay F. Piccirillo
- Publisher
- Elsevier BV
- Published
- 2021
- Language
- EN
- Field
- Medicine (Health Sciences)