Can I read Ventral pallido-striatal pathway in the rat brain: A light and electron microscopic study on EtoBox?

Ventral pallido-striatal pathway in the rat brain: A light and electron microscopic study by H. Kuo; H. T. Chang is a Neuroscience article available to read on EtoBox.

What is Ventral pallido-striatal pathway in the rat brain: A light and electron microscopic study about?

Most theories of basal ganglia functions have been based on a model circuit in which the flow of information follows a one-way loop proceeding from the cerebral cortex to the striatum, the palliduminigra, the thalamus, and then returns to the cortex. However, this model neglects data from several studies that show a direct feedback projection from the pallidum to the striatum. In this study, we have examined this feedback coiinection in the ventral striopallidal system to determine the morphology and chemical properties of ventral pallido-striatal projection neurons and to determine the morphology of ventral pallidal efferents in the ventral striatum. Fluoro Gold was injected into the ventral striatum to retrogradely label ventral pallidal projection neurons. Substance P immunoreactivity was used as a pallidal marker to delineate the ventral pallidum. The results show that most neurons retrogradely labeled by Fluoro Gold lie in the ventral pallidum. Additional double-labeling experiments show that none of these Fluoro Gold-labeled cells are cholinergic neurons; however, some are immunoreactive for parvalbumin, a calcium-binding protein found in many pallidal neurons. Electron micro

Who reads Ventral pallido-striatal pathway in the rat brain: A light and electron microscopic study?

Author

H. Kuo; H. T. Chang

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 0021-9967)

Published

1992

Language

EN

Field

Neuroscience (Life Sciences)