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Can I read Exercise training response according to baseline ferrokinetics in heart failure with preserved ejection fraction: A substudy of the TRAINING‐HF trial on EtoBox?
Exercise training response according to baseline ferrokinetics in heart failure with preserved ejection fraction: A substudy of the TRAINING‐HF trial by Patricia Palau; Laura López; Eloy Domínguez; Rafael de La Espriella; Raquel Campuzano; Almudena Castro; Gema Miñana; Agustin Fernández‐Cisnal; Juan Sanchis; Julio Núñez is a Medicine article available to read on EtoBox.
What is Exercise training response according to baseline ferrokinetics in heart failure with preserved ejection fraction: A substudy of the TRAINING‐HF trial about?
## Abstract ## Background Iron deficiency (ID) is associated with impaired functional capacity in patients with heart failure (HF), even in those with preserved ejection fraction (HFpEF). This study aimed to evaluate the effect of baseline ferrokinetics on peak oxygen consumption (peakVO~2~) improvement after a 12‐week physical therapy programme in patients with stable HFpEF. ## Methods This study is a post‐hoc sub‐analysis of a randomized clinical trial in which 59 stable patients with HFpEF were randomized to receive a 12‐week programme of inspiratory muscle training (IMT), functional electrical stimulation (FES), IMT + FES or usual care (UC) to evaluate change in peakVO~2~ (NCT02638961). Serum ferritin and transferrin saturation (TSAT) determinations were assessed at baseline. ID was defined as ferritin <100 ng/mL and/or TSAT <20% if ferritin was within 100–299 ng/mL. We used a linear mixed regression model to analyse between‐treatment changes in peakVO~2~ across ferrokinetics status at 12 and 24 weeks. ## Results The mean age was 74 ± 9 years, and 36 (61%) had ID. The mean of peakVO~2~ was 9.9 ± 2.5 mL/kg/min. The median of ferritin and transferrin saturation (TSAT) was 91 (50–
Who reads Exercise training response according to baseline ferrokinetics in heart failure with preserved ejection fraction: A substudy of the TRAINING‐HF trial?
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- Author
- Patricia Palau; Laura López; Eloy Domínguez; Rafael de La Espriella; Raquel Campuzano; Almudena Castro; Gema Miñana; Agustin Fernández‐Cisnal; Juan Sanchis; Julio Núñez
- Publisher
- John Wiley and Sons Inc.
- Published
- 2024
- Language
- EN
- Field
- Medicine (Health Sciences)