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Can I read Effect of an exogenous trigger on the pathogenesis of lupus in (NZB × NZW)F1 mice on EtoBox?
Effect of an exogenous trigger on the pathogenesis of lupus in (NZB × NZW)F1 mice by Hideo Yoshida; Minoru Satoh; Krista M. Behney; Chee-Gun Lee; Hanno B. Richards; Victoria M. Shaheen; Jun-Qi Yang; Ram R. Singh; Westley H. Reeves is a Medicine article available to read on EtoBox.
What is Effect of an exogenous trigger on the pathogenesis of lupus in (NZB × NZW)F1 mice about?
## Objective: This study examined the interactions between exogenous and endogenous factors shaping the phenotype of lupus in autoimmune (nzb x nzw)f(1) mice exposed to pristane, a model environmental trigger. ## Methods: Frequencies of various autoantibodies in untreated nzb/nzw mice were determined by various means (immunoprecipitation, enzyme-linked immunosorbent assay [elisa], crithidia luciliae kinetoplast staining). pristane or saline was administered intraperitoneally to 9-12-week-old nzb/nzw mice, followed by serial studies of autoantibodies, total ig levels (elisa), and proteinuria (dipstick). ## Results: Besides antichromatin/dna responses, nzb/nzw mice spontaneously produced novel autoantibodies against the double-stranded rna binding protein rna helicase a (rha). in contrast, nzb/nzw mice (n = 70) did not produce autoantibodies against the nuclear rnp (nrnp), sm, ro, or la antigens. pristane exposure synergistically activated the production of antichromatin/dna antibodies and dramatically accelerated renal disease. production of anti-nrnp/sm and su autoantibodies also was induced, indicating that the unresponsiveness of nzb/nzw mice to these antigens can be overcome. cu
Who reads Effect of an exogenous trigger on the pathogenesis of lupus in (NZB × NZW)F1 mice?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Hideo Yoshida; Minoru Satoh; Krista M. Behney; Chee-Gun Lee; Hanno B. Richards; Victoria M. Shaheen; Jun-Qi Yang; Ram R. Singh; Westley H. Reeves
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0004-3591)
- Published
- 2002
- Language
- EN
- Field
- Medicine (Health Sciences)