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PII-78Methadone dose ceilings and adverse events by K BELENDIUK; K PRESTON; J SCHMITTNER; J SCHROEDER; D EPSTEIN; S VOSKANIAN is a Medicine article available to read on EtoBox.

What is PII-78Methadone dose ceilings and adverse events about?

AIMS: To evaluate whether ANNs could predict accurate vancomycin trough concentrations in the intensive care unit (ICU) population compared to those predicted with a population pharmacokinetic model (pop-PK) and to assess the most significant inputs used in the ANN model. METHODS: Data of this pilot study, collected from 110 records of 41 patients who received vancomycin at the ICU, was used to train, validate and test various ANN models. A two hidden layers General Feed Foward network using the hyperbolic tangent function with four processing elements in each layer and a step learning rule was chosen to predict vancomycin trough concentrations. The proposed model was built with the Neurosolutions software (NeuroDimension, Inc). The criterion for judging the best model was the correlation coefficient (r test ) and the root mean square error (RMSE) between predicted and observed troughs in the testing set. Predictions from the ANN were compared to the pop-PK model using one way ANOVA and RMSE. ## RESULTS: The proposed ANN model predicted accurate vancomycin troughs with a r test of 0.93 and a RMSE of 10.72 compared to a RMSE of 41.01 for the pop-PK model. ANN predictions were not st

Who reads PII-78Methadone dose ceilings and adverse events?

Author

K BELENDIUK; K PRESTON; J SCHMITTNER; J SCHROEDER; D EPSTEIN; S VOSKANIAN

Publisher

Nature Publishing Group; Wiley (Blackwell Publishing); Wiley-Blackwell; Wiley; Springer Science and Business Media LLC; Research Square (ISSN 0009-9236)

Published

2006

Language

EN

Field

Medicine (Health Sciences)