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Systemic or Local Co-administration of Lactoferrin with Sensitizing Dose of Antigen Enhances Delayed Type Hypersensitivity in Mice by Michal Zimecki; Marian L Kruzel is a Immunology and Microbiology article available to read on EtoBox.
What is Systemic or Local Co-administration of Lactoferrin with Sensitizing Dose of Antigen Enhances Delayed Type Hypersensitivity in Mice about?
Lactoferrin (LF), a major defense protein synthesized and stored in granulocytes has been implicated in maintaining immune homeostasis during an insult-induced metabolic imbalance. In this study, we demonstrated that lactoferrin augments the delayed type hypersensitivity (DTH) response to specific antigens in mice. Lactoferrin (LF) was given to mice orally or intraperitoneally (i.p.) at the time of immunization, or subcutaneously (s.c.) in a mixture with the immunizing doses of the following antigens, sheep red blood cells (SRBC), Calmette-Guerin bacillus (BCG) or ovalbumin (OVA). A DTH reaction was determined 24 h after administration of an eliciting dose of antigen as a specific increase in foot pad swelling. Lactoferrin enhanced DTH reaction to all studied antigens in a dose-dependent manner. Lactoferrin (LF) given to mice in conjunction with antigen administered in an incomplete Freund's adjuvant induced the DTH response at the level of control mice given antigen in a complete Freund's adjuvant. In addition, LF remarkably increased DTH response to a very small, otherwise non-immunogenic SRBC dose. The increase in DTH response was less pronounced for orally administered LF than
Who reads Systemic or Local Co-administration of Lactoferrin with Sensitizing Dose of Antigen Enhances Delayed Type Hypersensitivity in Mice?
It is typically read by researchers, students, and practitioners in Immunology and Microbiology.
- Author
- Michal Zimecki; Marian L Kruzel
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0165-2478)
- Published
- 2000
- Language
- EN
- Field
- Immunology and Microbiology (Life Sciences)