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Thrombin Receptor Expression Is Upregulated in Prostate Cancer by Varsha Kaushal; Manish Kohli; Richard A. Dennis; Eric R. Siegel; Walter W. Chiles; Perkins Mukunyadzi is a Medicine article available to read on EtoBox.

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## Background: Aberrant expression of protease-activated receptors (pars) has been associated with increased angiogenesis, tumor growth, and metastasis of various cancers. we assessed the status of par1 expression in prostate cancer. ## Methods: The study compared the abundance levels of par1 rna and protein using real-time reverse-transcriptase polymerase chain reaction and immunoblotting in freshly resected prostate tissues from early localized-stage disease (n=9) to those from patients with advanced metastatic disease (n=7). par1 expression and localization was evaluated using immunohistochemical staining of prostate specimens with benign prostatic hyperplasia (n=27), early- (n=32) and advanced-stage (n=22) prostate cancer. association analyses of par1 expression with expression of vegf-family of growth factors, their receptors, and clinicopathological characteristics of the patients were also performed. ## Results: Par1 rna expression in advanced-stage prostate was 2.39-fold higher (p=0.024) and its protein expression was 2.75-fold higher (p=5.89x10(-5)) when compared with early-stage prostate cancer. par1 expression was localized to endothelial cells in vascular network of pro

Who reads Thrombin Receptor Expression Is Upregulated in Prostate Cancer?

Author

Varsha Kaushal; Manish Kohli; Richard A. Dennis; Eric R. Siegel; Walter W. Chiles; Perkins Mukunyadzi

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0270-4137)

Published

2006

Language

EN

Field

Medicine (Health Sciences)