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The permeation of organic cations through cAMP-gated channels in mammalian olfactory receptor neurons by S. Balasubramanian; J. W. Lynch; P. H. Barry is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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The permeation of monovalent organic cations through adenosine 3',5'-cyclic monophosphate-(cAMP) activated channels was studied by recording macroscopic currents in excised inside-out membrane patches from the dendritic knobs of isolated mammalian olfactory receptor neurons (ORNs). Current-voltage relations were measured when bathing solution Na+ was replaced by monovalent organic cations. Permeability ratios relative to Na+ ions were calculated from changes in reversal potentials. Some of the small organic cations tested included ammonium (NH4+), hydroxylammonium and formamidinium, with relative permeability ratios of 1.41, 2.3 and 1.01 respectively. The larger methylated and ethylated ammonium ions studied included: DMA (dimethylammonium), TMA (tetramethylammonium) and TEA (tetraethylammonium) and they all had permeability ratios larger than 0.09. Even large cations such as choline, arginine and tris(hydroxymethyl)aminomethane (Tris) were appreciably permeant through the cAMP-activated channel with permeability ratios ranging from 0.19 to 0.7. The size of the permeating cations, as assessed by molecular weight, was a good predictor of the permeability. The permeability sequence o

Who reads The permeation of organic cations through cAMP-gated channels in mammalian olfactory receptor neurons?

Author

S. Balasubramanian; J. W. Lynch; P. H. Barry

Publisher

Springer; Springer-Verlag; Springer Verlag; Springer Science and Business Media LLC (ISSN 0022-2631)

Published

1995

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)