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Genetic variants in the promoters of let-7 are associated with the risk and age at onset of ischemic stroke: A case control study by Yuye Wang; Luying Qiu; Wenjuan Jiang; Meilin Chen; Zhiyi He; Yanzhe Wang; Shumin Deng is a Medicine article available to read on EtoBox.
What is Genetic variants in the promoters of let-7 are associated with the risk and age at onset of ischemic stroke: A case control study about?
Purpose Let-7 family members serve as crucial regulatory molecules in the pathogenesis of ischemic stroke. We predicted that genetic variations in the let-7 family's promoters may be linked to the risk of ischemic stroke. The connection of rs10877887 and rs13293512 in the let-7 family promoters with liability to ischemic stroke was explored in this study. Patients and methods Clinical data and peripheral blood samples were collected from 914 ischemic stroke patients and 836 controls in this case–control study. All statistical analyses were carried out using SPSS. Results Our analysis results reveal that the rs10877887 TC+CC genotype in the dominant model is associated with a lower risk of ischemic stroke than the TT genotype. Individuals with heterozygous TC or homozygous CC genotypes in the male population showed higher odds of ischemic stroke than those with the wild TT genotype in rs13293512 analysis. Furthermore, there existed a multiplicative interaction between the rs10877887 C allele and the rs13293512 T allele. In the presence of the rs13293512 T allele, the effect of the rs10877887 C allele on ischemic stroke risk was increased. Similarly, in the presence of the rs10877887
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- Author
- Yuye Wang; Luying Qiu; Wenjuan Jiang; Meilin Chen; Zhiyi He; Yanzhe Wang; Shumin Deng
- Publisher
- Elsevier BV
- Published
- 2023
- Language
- EN
- Field
- Medicine (Health Sciences)