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This study examined the pharmacokinetics of the local anesthetic ropivacaine and its metabolites in patients with chronic renal failure compared with healthy volunteers. The study found that renal dysfunction had little effect on the pharmacokinetics of ropivacaine itself. However, the metabolite PPX is primarily excreted by the kidneys, so its clearance correlated with renal function. While non-renal elimination of PPX helped compensate for reduced renal clearance in most patients, two patients showed incr

Author

RENAULT

Language

EN