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Progress and prediction of multicomponent quantification in complex systems with practical LC-UV methods by Xi Chen; Zhao Yang; Yang Xu; Zhe Liu; Yanfang Liu; Yuntao Dai; Shilin Chen is a Chemistry article available to read on EtoBox.

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Complex systems exist widely, including medicines from natural products, functional foods, and biological samples. The biological activity of complex systems is often the result of the synergistic effect of multiple components. In the quality evaluation of complex samples, multicomponent quantitative analysis (MCQA) is usually needed. To overcome the difficulty in obtaining standard products, scholars have proposed achieving MCQA through the “single standard to determine multiple components (SSDMC)” approach. This method has been used in the determination of multicomponent content in natural source drugs and the analysis of impurities in chemical drugs and has been included in the Chinese Pharmacopoeia. Depending on a convenient (ultra) high-performance liquid chromatography method, how can the repeatability and robustness of the MCQA method be improved? How can the chromatography conditions be optimized to improve the number of quantitative components? How can computer software technology be introduced to improve the efficiency of multicomponent analysis (MCA)? These are the key problems that remain to be solved in practical MCQA. First, this review article summarizes the calculat

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Author

Xi Chen; Zhao Yang; Yang Xu; Zhe Liu; Yanfang Liu; Yuntao Dai; Shilin Chen

Publisher

Elsevier BV

Published

2022

Language

EN

Field

Chemistry (Physical Sciences)