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Biotransformation refers to the chemical conversion of drugs into metabolites, primarily occurring in the liver, which can lead to pharmacological inactivation. The process involves two phases: Phase I reactions (oxidation, reduction, hydrolysis) that introduce polar functional groups, and Phase II reactions (conjugation) that enhance water solubility for excretion. Various factors such as drug properties, enzyme induction/inhibition, biological differences, and environmental influences significantly affect

Author

thiruviji2022

Language

EN