Opening book details…
Can I read Glucocorticoids Increase Interleukin-6-dependent Gene Induction by Interfering with the Expression of the Suppressor of Cytokine Signaling 3 Feedback Inhibitor on EtoBox?
Glucocorticoids Increase Interleukin-6-dependent Gene Induction by Interfering with the Expression of the Suppressor of Cytokine Signaling 3 Feedback Inhibitor by Anna Dittrich; Christina Khouri; Sara Dutton Sackett; Christian Ehlting; Oliver Böhmer; Ute Albrecht; Johannes G. Bode; Christian Trautwein; Fred Schaper is a Medicine article available to read on EtoBox.
What is Glucocorticoids Increase Interleukin-6-dependent Gene Induction by Interfering with the Expression of the Suppressor of Cytokine Signaling 3 Feedback Inhibitor about?
Glucocorticoids are known to be potent regulators of inflammation and have been used pharmacologically against inflammatory, immune, and lymphoproliferative diseases for more than 50 years. Due to their possible and well-documented side effects, it is crucial to understand the molecular mechanisms and targets of glucocorticoid action in detail. Several modes of action have been discussed; nevertheless, none of them fully explain all the functions of glucocorticoids. Therefore, we analyzed the cross-talk between glucocorticoids and interleukin-6 (IL-6) in the liver. IL-6 exerts pro-inflammatory as well as antiinflammatory properties and is a main inducer of the acute-phase response. The balance between the proinflammatory and anti-inflammatory activities of IL-6 is tightly regulated by suppressor of cytokine signaling 3 (SOCS3), a well-known feedback inhibitor of IL-6 signaling. Here, it is demonstrated that glucocorticoids enhance IL-6-dependent c-fibrinogen expression. Studying of the underlying mechanism revealed prolonged activation of signal transducer and activator of transcription 3 (STAT3) caused by down-regulation of SOCS3 protein expression. Consequently, in SOCS3-deficien
Who reads Glucocorticoids Increase Interleukin-6-dependent Gene Induction by Interfering with the Expression of the Suppressor of Cytokine Signaling 3 Feedback Inhibitor?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Anna Dittrich; Christina Khouri; Sara Dutton Sackett; Christian Ehlting; Oliver Böhmer; Ute Albrecht; Johannes G. Bode; Christian Trautwein; Fred Schaper
- Publisher
- Ovid Technologies (Wolters Kluwer Health)
- Published
- 2011
- Language
- EN
- Field
- Medicine (Health Sciences)