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Comprehensive analysis of 34 MiT family translocation renal cell carcinomas and review of the literature: investigating prognostic markers and therapy targets by Anna Caliò; Matteo Brunelli; Diego Segala; Serena Pedron; Andrea Remo; Serena Ammendola; Enrico Munari; Francesco Pierconti; Alessandra Mosca; Enrico Bollito; Angelo Sidoni; Simona Fisogni; Cosimo Sacco; Luisa Canu; Steno Sentinelli; Anna Paola Fraccon; Michelangelo Fiorentino; Cathryn Scott; Michele Milella; Camillo Porta; Pedram Argani; Guido Martignoni is a Medicine article available to read on EtoBox.

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Recently cabozantinib, a tyrosine kinase inhibitor with activity against VEGF, MET, AXL, and downregulating cathepsin K in vitro, has been proposed for the treatment of advanced clear and non-clear renal cell carcinomas. Since it is well known that cathepsin K is expressed in the majority of MiT family translocation renal cell carcinomas, we investigated cathepsin K, MET, AXL, and VEGF in a large series of those tumours, looking for possible predictive markers. We collected the clinicopathological features of 34 genetically confirmed MiT family translocation renal cell carcinomas [26 Xp11 and 8 t(6;11) renal cell carcinomas] and studied them using an immunohistochemical panel including PAX8, cathepsin K, HMB45, Melan-A, CD68 (PG-M1), CK7, CA9, MET, AXL and by FISH for VEGFA and MET. Cathepsin K was expressed in 14 of 26, HMB45 in 8 of 25, and Melan-A in 4 of 23 Xp11 renal cell carcinomas, whereas labelling for CK7 and CA9 was minimal. In t(6;11) renal cell carcinoma, cathepsin K and melanogenesis markers were constantly positive, whereas CK7 and CA9 were negative. None of the 34 carcinomas showed CD68 (PG-M1) and AXL expression. One aggressive Xp11 renal cell carcinoma showed incre

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Author

Anna Caliò; Matteo Brunelli; Diego Segala; Serena Pedron; Andrea Remo; Serena Ammendola; Enrico Munari; Francesco Pierconti; Alessandra Mosca; Enrico Bollito; Angelo Sidoni; Simona Fisogni; Cosimo Sacco; Luisa Canu; Steno Sentinelli; Anna Paola Fraccon; Michelangelo Fiorentino; Cathryn Scott; Michele Milella; Camillo Porta; Pedram Argani; Guido Martignoni

Publisher

Informa plc; Elsevier ; Elsevier BV (ISSN 0031-3025)

Published

2020

Language

EN

Field

Medicine (Health Sciences)