Opening book details…
Can I read Expression of apoptosis-related proteins, p53, and DNA fragmentation in sarcomas of the pulmonary artery on EtoBox?
Expression of apoptosis-related proteins, p53, and DNA fragmentation in sarcomas of the pulmonary artery by Andreas Gaumann; Dominique S. Tews; Eckhard Mayer; Manfred Dahm; Peter K. Petrow; Mike Otto; C. James Kirkpatrick; Jrg Kriegsmann is a Medicine article available to read on EtoBox.
What is Expression of apoptosis-related proteins, p53, and DNA fragmentation in sarcomas of the pulmonary artery about?
## Background: Apoptosis is a common feature in a variety of pathologic conditions. induction of apoptosis through apoptotic stimuli such as, chemotherapy or radiation, presents new insights into tumor biology and therapy. in particular, members of the bcl-2 family as well as the fas system are known to be involved in the regulation of apoptosis in different tumor entities. ## Methods: In the current study, the expression of the apoptosis-related molecules p53, bax, bcl-2, fas (cd95), fas-ligand and perforin was examined in 7 patients with a sarcoma of the pulmonary artery. furthermore, the tunel-method for the detection of apoptotic cells was applied as well as sequencing of the p53 gene. ## Results: In the tunel assay, approximately 10% of the sarcoma cells displayed dna fragmentation. in addition, bax was expressed in tumor cells. accumulation of p53 was evident in 4 of 7 patients (pab 240 antibody), and 2 of them were positive for the pab 1801 antibody. only 1 case had a point mutation in exon 5 of the p53 sequence. a few tumor cells showed a double labeling of bax and p53. bcl-2 could be detected only in tumor-associated lymphocytes. finally, several lymphocytes could be stain
Who reads Expression of apoptosis-related proteins, p53, and DNA fragmentation in sarcomas of the pulmonary artery?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Andreas Gaumann; Dominique S. Tews; Eckhard Mayer; Manfred Dahm; Peter K. Petrow; Mike Otto; C. James Kirkpatrick; Jrg Kriegsmann
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0008-543X)
- Published
- 2001
- Language
- EN
- Field
- Medicine (Health Sciences)