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Mouse Ror2 receptor tyrosine kinase is required for the heart development and limb formation by Shigeto Takeuchi; Kiyoshi Takeda; Isao Oishi; Masashi Nomi; Makoto Ikeya; Kyoko Itoh; Shingo Tamura; Takahiro Ueda; Toshihisa Hatta; Hiroki Otani; Toshio Terashima; Shinji Takada; Hirohei Yamamura; Shizuo Akira; Yasuhiro Minami is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
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## Backgrounds A mouse receptor tyrosine kinase (RTK), mRor2, which belongs to the Ror‐family of RTKs consisting of at least two structurally related members, is primarily expressed in the heart and nervous system during mouse development. To elucidate the function of mRor2, we generated mice with a mutated mRor2 locus. ## Results Mice with a homozygous mutation in mRor2 died just after birth, exhibiting dwarfism, severe cyanosis, and short limbs and tails. Whole‐mount __in situ__ hybridization analysis showed that mRor2 was expressed in the branchial arches, heart and limb/tailbuds, in addition to the developing nervous system. The mutants had cardiac septal defects, mainly a ventricular septal defect. In addition, an examination of the skeletal systems revealed that the mutants had shorter limbs, vertebrae and facial structure, with a particular defect in their distal portions, and that almost no calcification was observed in their distal limbs. Histological examination showed abnormalities in the chondrocytes. ## Conclusions Our findings suggest that mRor2 plays essential roles in the development of the heart and in limb/tail formation, in particular cardiac septal formation and
Who reads Mouse Ror2 receptor tyrosine kinase is required for the heart development and limb formation?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Shigeto Takeuchi; Kiyoshi Takeda; Isao Oishi; Masashi Nomi; Makoto Ikeya; Kyoko Itoh; Shingo Tamura; Takahiro Ueda; Toshihisa Hatta; Hiroki Otani; Toshio Terashima; Shinji Takada; Hirohei Yamamura; Shizuo Akira; Yasuhiro Minami
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 1356-9597)
- Published
- 2000
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)